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ʻO ka pauma Alpha-lipoic Acid (1077-28-7)

ʻO ka waikawa Alpha-lipoic acid / thioctic acid kahi pauka e like me ka wikamina i kapa ʻia he antioxidant. ʻO ka hū, ke ake, nā puʻupaʻa, ka milo, ka broccoli, a me nā ʻuala i waiwai maikaʻi ofalpha-lipoic acid / thioctic acid. Hana ʻia ia i loko o ka hale hana no ka hoʻohana ʻana i ka lāʻau. ʻO ka waha alpha-lipoic acid / thioctic acid ka mea i lawe pinepine ʻia e ka waha no ka maʻi diabetes a me nā ʻōuli e pili ana i ka maʻi kō me ka ʻeha ʻana, ka ʻeha, a me ka helu o nā wāwae a me nā lima. Hāʻawi ʻia ia ma ke ʻano he injection i ke aa (e IV) no kēia mau hoʻohana like. ʻĀpana kiʻekiʻe o ka alpha-lipoic acid / thioctic acid i ʻae ʻia i Kelemania no ka mālama ʻana i kēia mau ʻōuli e pili ana i ke aʻalolo.

Hana: Hana Hana
pūʻolo: 1KG / ʻeke, 25KG / pahu
Hiki i ka Wisepowder ke hana a hāʻawi i ka nui. ʻO nā hana a pau ma lalo o ke kūlana cGMP a me ka ʻōnaehana hoʻomalu maikaʻi koʻikoʻi, loaʻa nā palapala hoʻāʻo a pau.
Māhele:

Alpha-lipoic Acid powder Base ʻike

 

inoa ʻO ka paukū Acid Alpha-lipoic
CAS 1077-28-7
Purity 98%
Inoa inoa inoa (+/-) - 1,2-Dithiolane-3-pentanoic ʻAikika; (+/-) - 1,2-Dithiolane-3-valericʻakika; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -α-Lipoic ʻAikika
'O Synonyms DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipothion; NSC 628502; NSC 90788; Protogen A; Thioctsan; Tioctacid;
Ka Lā Molecular C8H14O2S2
Molecular Weight 206.318 g / mol
Point Hoʻolālā 60-62 ° C
InChI Key AGBQKNBQESQNJD-UHFFFAOYSA-N
ano paa
Keʻano Mālamalama i Kunani
Half Ole 30 mau minuke i ka hola
Palekana Hoʻopiliʻia i loko o Chloroform (Lohi), DMSO (Lohi), Methanol (Lohi iki)
pūnaewele Kūlana: Maloʻo, ʻeleʻele a ma 0 - 4 C no ka wā pōkole (mau lā a i mau pule) a i ʻole -20 C no ka wā lōʻihi (mau mahina i mau makahiki).
noi He kumu hoʻoikaika lemak-metabolism.
Hōʻike hōʻike palapala Available
Hōʻikeʻike Alpha-lipoic
Kiʻi pauda
Light Yellow

 

He aha ka Acid Alpha-lipoic?

ʻO Alpha-lipoic acid kahi antioxidant i lawe ʻia mai ka waikawa caprylic. ʻO kona mau inoa ʻē aʻe he ALA, acid lipoic, Biletan, Lipoicin, Thioctan, a me nā mea ʻē aʻe he 1,2-dithiolane-3-pentanoic acid a i ʻole thioctic acid. ʻO ia kahi hui organosulfur a hana ʻia i loko o ke kino o nā kānaka a me nā holoholona. Hana ʻia kāna hana mai ka octanoic acid a me ka cysteine ​​ma ke ʻano he kumu sulfur. He waiwai nui ia no kaobobob aerobic i loko o ke kino. Aia ia i kēlā me kēia cell a kōkua i ka hana ʻana i ka ikehu mai ka glucose.

He nui nā hana pūnaewele a me nā mole, no ka mea o kāna mau antioxidant hiki. ʻO kēia hana antioxidative o alpha-lipoic acid i hāpai i kona hoihoi no ka hoʻohana ma ke ʻano he nutritive supplement. Hoʻohana ʻia ia ma ke ʻano he agena lapaʻau. He lapaʻau kūpono paha ia i ka maʻi diabetes, ka pohō kaumaha, neuropathy ma muli o ka maʻi diabetes, hoʻōla i ka ʻeha, hoʻomaikaʻi i nā kūlana o ka ʻili, etc.

He hapa hapalua ko ke alpha-lipoic acid pau he 30 mau minuke i hoʻokahi hola. Māmā iki ia i ka chloroform, dimethyl sulokside (DMSO), a me ka methanol. Hiki ke kiʻi ʻia mai ka milo, ka hū, broccoli, kaʻuala, kaʻiʻo e like me ke ake a me ka puʻupaʻa.

ʻO ka mahele lāʻau nui i hiki i ke kanaka makua ke lawe i hoʻokahi lā ʻo 2400mg.

 

Pehea e holo ai ʻo Alpha-lipoic Acid?

ʻO ka Alpha-lipoic acid kahi waiwai antioxidant. ʻO ia ka mea hiki ke hakakā kūʻē i nā radical manuahi i ke kino a hoʻolohi i nā hanana e like me ka ʻelemakule o ke kelepona a kōkua i ka mālama ʻana i nā pūnaewele olakino.

Hana ʻia ia i ka mitochondria a hana ma ke ʻano he cofactor nui no ka wāwahi ʻana i nā enzymes a me nā meaola. Hoʻopili pū ia i nā iona hao a hoʻoliʻiliʻi i ke ʻano oxidized o nā antioxidants ʻē aʻe e like me ka wikamina C, Vitamin E, a me glutathione. Hiki iā ia ke hoʻoponopono hou iā lākou. Pono ka acid Alpha-lipoic no ka kaohi ʻana i nā ʻano oxygen reactive.

Paipai pū kekahi ʻo Alpha-lipoic acid i ka ʻōnaehana paleʻāina anti-antioxidant. Hana ia i kēia ma o Nrf-2-mediated genedant antioxidant. Hoʻololi pū kekahi i nā ʻāpana e pono ai kahi proliferator peroxisome e hoʻoiho iā lākou.

Hoʻopau pū kekahi ʻo Alpha-lipoic acid i ka kappa B. mea hoʻouluulu i ka kinase protein i hoʻoulu ʻia e AMP-AMP (AMPK) i nā mākala iwi a hana i nā hana metabolic like ʻole.

ʻElua ʻano o ka alpha-lipoic acid. ʻO lākou ka waikawa lipoic oxidized (LA) a hoʻemi ʻia ka dihydrolipoic acid (DHLA). Hana ʻia ʻo DHLA i ka mitochondria e loaʻa ana nā hunaola i loko o ke kino. Hiki i kēia me ka nicotinamide adenine dinucleotide hydrogen (NADH) a me ka lipoamide dehydrogenase. Kōkua kēia mau mea ʻelua i kēia hoʻohuli hoʻololi ʻana.

I nā pūnaewele i nele i ka mitochondria, hiki i ka alpha-lipoic acid ke hoʻemi ʻia i DHLA ma o ka nicotinamide adenine dinucleotide phosphate (NADPH). Kōkua ʻia kēia hana e glutathione a me thioredoxin reductases.

He waiwai ʻokoʻa kā ka Alpha-lipoic acid i mea ʻokoʻa ia mai ka glutathione. ʻOiai ʻo ka hoʻemi ʻia o ka glutathione kahi antioxidant, ʻo nā ʻāpana alpha-lipoic acid i hoʻemi ʻia a hoʻemi ʻia hoʻi he mau antioxidants ikaika.

Hoʻokomo pū ʻia ʻo Alpha-lipoic acid i ka hoʻoponopono ʻana i nā proteins oxidized a hiki ke kōkua i ke kaohi o ka transcription gene.

ʻO ka Alpha-lipoic acid kekahi mau ʻano anti-inflammatory pū kekahi. Hoʻopau ia i ka kappa B kinase, kahi enzyme e hoʻoulu i ka NF-kB, ke kumu e hoʻololi ai i nā cytokine inflammatory [1].

 

Mōʻaukala o Alpha-lipoic Acid

Ua loaʻa ʻo Alpha-lipoic acid i ka makahiki 1937 e Snell. I kēlā manawa, ke aʻo ʻepekema nei i kekahi ʻano bacteria i hoʻohana i ka wai ʻuala no ka hoʻohua hou. 1n 1951, ua kaʻawale ia e Reed. Hoʻomaka ka hoʻohana lapaʻau mua loa ma Kelemania i 1959 no ka mālama ʻana i ka lāʻau make ma muli o nā ʻalalā pāpale make.

ʻO ka ʻike e pili ana i ka hoʻohana ʻia o ka alpha-lipoic acid a me kāna hopena ʻaʻole i pau. ʻAʻole i hōʻoia ʻia ka hoʻohana ʻana i ka lāʻau lapaʻau e ka FDA. Akā i loko o nā makahiki, ua loaʻa ka mahalo ʻia ma ke ʻano he supplement.

 

He aha nā hopena ʻē aʻe o ka Acid Alpha-lipoic?

E like me ka nui o nā lāʻau ʻē aʻe, loaʻa nā hopena ʻē aʻe i ka alpha-lipoic acid.

ʻO kekahi o nā hopena hopena maʻamau o ka alpha-lipoic acid ʻo:

  • Heʻeha
  • Kuʻikena
  • 'O Nausea
  • ʻO ka wai
  • Ke olakino
  • ʻO ke kukui
  • Ke koko koko
  • Paheʻe kaʻili
  • Kuhiau

ʻAʻole ʻike ʻia nā hopena o ka pauma acid-lipoic acid i nā makuahine hāpai a hānai. No laila koi ʻia e hōʻalo i ka hoʻohana ʻana i kēia ke hāpai a hānai waiu paha.

 

He aha nā pono o ka Alpha-lipoic Acid?

Nui nā keu pono o ka alpha-lipoic acid. O lākou:

 

Ka hopena ma ka maʻi Alzheimer

Hiki i ka alpha-lipoic acid pauka ke hoʻolohi i ka hoʻomaka a hoʻolohi paha i ka holomua o ka maʻi neurodegenerative. Ua mālama ʻia kahi noiʻi ma ʻeiwa mau maʻi me ka maʻi ʻo Alzheimer. Hāʻawi ʻia ʻo 600mg o ka waikawa Alpha-lipoic i kēlā me kēia lā no 12 mau mahina [2]. Ua hiki iā ia ke hoʻokūpaʻa i ka naʻau i kēia mau maʻi. Hiki i kāna waiwai antioxidant ke hoʻolohi i ke ʻano a hana paha ma ke ʻano he neuroprotective agents.

 

Hana ma ka maʻi diabetes

Hiki i ka Alpha-lipoic acid ke kōkua i ka hoʻohaʻahaʻa i nā pae kō kō i nā maʻi diabetic. ʻOiai hiki i kāna mau waiwai antioxidant ke kāpae i nā radical manuahi i loko o ke kino, hiki iā ia ke kōkua i ka mālama ʻana i ka pōʻino o nā hunaola i hoʻokumu ʻia e ka maʻi kō. Hiki iā ia ke hoʻomaikaʻi i ke kūpaʻa o ka insulin i nā poʻe diabetes. Hiki iā ia ke pale i ka make ʻana o nā hunaola beta a hoʻonui paha i ka lawe ʻana o ka glucose a hoʻolohi i nā pilikia o ka maʻi kō, ʻo ia hoʻi ka neuropathy diabetic [3].

 

Ka hopena ma ke Kahakaha

Loaʻa nā mana neuroprotective ʻo Alpha-lipoic acid. Hiki i kāna mau hana antioxidant ke kōkua pū i ka hoʻonui ʻana o ka neuron i ka lolo i loaʻa i ka maʻi hahau. ʻO kahi noiʻi i hana ʻia ma nā ʻiole me ka hahau ischemic i hāʻawi ʻia i ka alpha-lipoic acid hōʻike i kahi hoʻomaikaʻi i ko lākou kūlana [4]. No laila, kōkua paha ia e hoʻomaikaʻi i ke ʻano o nā mea maʻi hahau.

 

Ka hopena ma ka ʻelemakule

Hiki paha i ka alpha-lipoic acid pauka ke kōkua i ka hoʻolōʻihi i ka ʻelemakule o ka ʻili. Hiki i ka Alpha-lipoic acid ke hāʻawi i hoʻokahi electron i ka ʻili-ʻino a me ka ʻelemakule-e hana ana i nā mea hana a oxidize iā ia iho. Hiki i kēia ala ke ho'ōki i kaʻelemakule a hiki ke hoʻopihapiha i ka hana o ka hemahema antioxidant mea [5]. Hiki paha i kēia ke kōkua i ke kūʻē i nā mea i hōʻino ʻia e nā ʻano mea like ʻole.

 

Ka hopena ma Mercury Poisoning a me Autism

Hiki i ka Alpha-lipoic acid ke hala i ka pale o ka lolo. Hoʻohana ʻia paha ia e detoxify mercury i hoʻopili ʻia i nā hunaola o ka lolo inā loaʻa ka lāʻau make mercury [6]. Hiki iā ia ke hoʻoliʻiliʻi i ka mercury i hoʻopaʻa ʻia i loko o ke kahe o ke koko mai kahi e hiki ai i nā mea chelator ʻē aʻe e like me dimercaptosuccinic acid (DMSA) a i ʻole methylsulfonylmethane (MSM) ke hoʻololi i ka mercury i loko o nā puʻupaʻa a laila e hemo i ka mimi. ʻAʻole hiki i DMSA a i ʻole MSM keʻa aʻe i ka pale o ka lolo-koko, me ka hoʻohana ʻana i ka waikawa alpha-lipoic me DMSA i hiki ke kōkua i ka lawe palekana ʻana i ka mercury. Hiki paha i kēia ke kōkua i ka mālama ʻana i ka autism e like me ke kiʻekiʻe o ka mercury o nā keiki autistic i ka hoʻohālikelike ʻia me ka maʻamau. Eia nō naʻe, kaupalena ʻia nā noiʻi ʻana e pili ana i kēia.

 

Ka hopena ma Anemia

Ua mālama ʻia kahi noiʻi i nā mea maʻi me nā maʻi ʻōiwi hopena me ka anemia kahi i hāʻawi ʻia ai ka alpha-lipoic acid i nā mea maʻi [7]. Ua hōʻike ʻia e hiki ke like me ka erythropoietin i ka hoʻonui ʻana i nā pae o hemoglobin me ka ʻole o nā hopena ʻino. No laila, kōkua ia i ka mālama ʻana i ka anemia i hoʻokumu ʻia e ka hopena hōʻino pae hope loa. He pōmaikaʻi waiwai paha ia.

 

ʻO ke ʻano he Antioxidant

ʻOiai ʻo ka pauma alpha-lipoic acid he antioxidant, he nui nā pono a hiki ke kōkua me nā ʻano he nui i ke kino.

 

Ka hopena ma Neurotoxicity Ma muli o ka Alcoholism

Hiki i ka waiʻona ke hana i nā maʻi neurological ma muli o ke koʻikoʻi oxidative. Hiki i ka Alpha-lipoic acid ke kōkua i ka mālama ʻana i ka neurotoxicity ma muli o ka ʻalekohola. Hiki iā ia ke pale i ka hoʻā o ka protein i kū i ka lawe ʻana o ka ethanol [8].

 

Ka hopena ma ka pohō kaumaha

ʻO Alpha-lipoic acid kekahi mea kōkua maikaʻi no ke kōkua ʻana i ka lilo ʻana o ke kaupaona no ka poʻe kaupaona a me ka poʻe momona. Loaʻa nā hopena ʻē aʻe i ka hoʻohālikelike ʻia me nā lāʻau hōʻemi kaumaha a loaʻa nā antioxidant i hiki ke kōkua i ka mālama ʻana i ke kanaka olakino.

 

Kū'ē

ʻAʻole nui nā noiʻi e pili ana i nā contraindications o ka alpha-lipoic acid. Eia nō naʻe, pono makaʻala kekahi mau mea maʻi me kekahi mau kūlana ma mua o ka hoʻohana ʻana i kēia mea a nīnau aku me ke kauka ma mua o ka hoʻohana ʻana ia mea.

ʻO kekahi o kēia mau ʻano:

  • ʻO ka maʻi maʻi
  • Ka hoʻohanaʻana i ka waiʻona ikaika
  • Maʻi thyroid
  • Thiamine nele

 

Nā launa lāʻau me ka Acid Alpha-lipoic

ʻAʻole nui ka ʻike e pili ana i ka pilina o ka alpha-lipoic acid me nā lāʻau ʻē aʻe. Akā ʻoi aku ka maikaʻi o ka hōʻalo ʻana i kekahi mau lāʻau me kēia kumukanawai.

ʻO kekahi o kēia mau lāʻau:

Nā Laʻau Hypoglycemic - Loaʻa i ka Alpha-lipoic kō kō e hoʻemi ana i ka hiki. I kekahi mau hihia hiki iā ia ke kumu i ka insulin autoimmune Syndrome, e alakaʻi ana i ka hypoglycemia. No laila ke hoʻohana nei ia me nā lāʻau hypoglycemic e kumu i ka hypoglycemia wikiwiki e weliweli paha.

Nā lāʻau lapaʻau thyroid - Hiki i ka Alpha-lipoic acid ke hoʻohaʻahaʻa i ke kiʻekiʻe o nā homone thyroid. No laila koi ʻia ka nānā pono ʻana ke hoʻohana ʻia me ka levothyroxine.

 

Ma hea ʻoe e kūʻai ai i ka Acid Alpha-lipoic i 2021?

Hiki iā ʻoe ke kūʻai pololei mai i ka pauma acid alpha-lipoic mai ka ʻoihana hana alfa-lipoic acid. Loaʻa iā ia i kahi melemele māmā i ka pauka melemele. Hoʻokomo ʻia ia i kahi pūʻolo o 1 kg i kēlā me kēia packet a me 25kg no kēlā me kēia pahu. Eia naʻe, hiki ke hoʻololi i kēia e like me nā makemake o ka mea kūʻai mai.

Pono e mālama ʻia i kahi mahana o 0 a 4 ° C no ka wā pōkole a -20 ° C no ka wā lōʻihi. Pono ia i kahi anuanu, ʻeleʻele, a maloʻo hoʻi no ka mālama ʻana e pale ai iā ia mai ka hopena ʻana me nā kemika ʻē aʻe i ke kaiapuni. Hana ʻia kēia huahana mai nā mea hoʻohui maikaʻi loa e pili ana i nā kaho kūpono.

 

Nā kūmole i haʻi ʻia

  1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Hana ʻo Alpha-lipoic acid i nā hopena anti-inflammatory ma lipopolysaccharide-stimulate rat mesangial cells ma o ka pāpā ʻana o ka nukelea kappa B (NF-κB) ala hōʻailona. li nui, 38(2), 510-519.
  2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid ma ke ʻano he koho koho hou no ka maʻi o Alzheimer — He 48 mau ana ka loiloi ma hope. I loko o Nā maʻi Neuropsychiatric kahi hoʻokokoke hoʻohui(pp. 189-193). ʻO Springer, Vienna.
  3. Laher, I. (2011). Diabetes a me ka alpha-lipoic acid. Nā pale āpau i nā lāʻau lapaʻau, 2, 69.
  4. Choi, KH, Pāka, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). ʻO ka mālama ʻana i ka acid Alpha-lipoic ka neurorestorative a paipai i ka hana hou ʻana ma hope o ka hahau ʻana o nā ʻiole. Lolo lolo, 8(1), 1-16.
  5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Ka hopena o ka waikawa α-Lipoic ma ka hoʻomohala ʻana i nā kūlike o ka ʻili kanaka me ka hoʻohana ʻana i kahi hiʻohiʻona Pumpless Skin-on-a-Chip. ʻO ka International Journal of Molecular Sciences, 22(4), 2160.
  6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). ʻIke i nā alpha-lipoic a me dihydrolipoic acid e like me nā scavenger hoʻohiki o ke kaumaha oxidative a me nā chelators hiki i ka mercury toxology. Ka puke pai o ka biochemistry inorganic, 195, 111-119.
  7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Ke kuleana o ka alpha-lipoic acid i ka mālama ʻana i ka anemia i nā mea maʻi me ka hōʻino ʻole o ke kōpaʻa mau loa e hana ana i ka hemodialysis. ʻO ka puke pai kūwaho o nephrology a me nā maʻi hou, 6, 161.
  8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Pale ka Alpha-lipoic acid i ka oxidation protein i hoʻokomo ʻia e ka etanol i loko o nā iole hippocampal HT22. Nā Neuroscience Letters, 328(2), 93-96.
  9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). ʻO Alpha ‐ lipoic acid (ALA) ma ke ʻano he kōkua no ka pohō kaumaha: nā hopena mai ka meta-analysis o nā hoʻokolohua hoʻokolohua kaulike ʻole ʻia. ʻOi nui Reviews, 18(5), 594-601.

 

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