Kaumakaiwaʻi

Aging & Antiaging (Anti-ʻelemakule)

ʻO ka ʻelemakule kahi mea a mākou e hana āpau akā maopopo iki. Hiki i kou lolo ke loli i kou mau makahiki i loaʻa i nā hopena liʻiliʻi i kou hoʻomanaʻo a i ʻole kou noʻonoʻo ʻana. Maʻalahi e hana i kahi papa inoa o nā hoʻololi āpau i hiki mai me nā makahiki - ka hoʻomanaʻo ʻana o ka hoʻomanaʻo, nā ʻākī, ka nalo ʻana o nā mākala.
ʻO ka pale ʻana (anti-old) hiki ke lilo i kumuhana paʻakikī e kūkākūkā: i ke kaua i kēia manawa ke kaua ma luna o ka manaʻo o ka huaʻōlelo i ka noiʻi a me ka lāʻau lapaʻau, a me ka mea no nā huahana ma kahi mauʻae a me ka hoʻopunipuni pinepine ʻole.
ʻO Antiaging (Anti-kahiko) i kēia manawa he nui nā manaʻo maʻamau a me nā moʻo ʻana.
-Ma ka ʻepekema kaiāulu anti-kahiko (antiaging) noiʻi ʻokoʻa loa i ka hoʻolōʻihi, pale ʻana, a hoʻi ʻana paha i ke kaʻina hana kahiko. ʻOiai ke nānā nei ka wā e hiki mai ana, aia i kēia manawa ʻaʻohe hōʻoia a loaʻa i kahi ʻenehana lapaʻau e pīhoihoi ana a hoʻohuli paha i ka wā kahiko i loko o nā kānaka.
-Ma ke kaiāulu ʻoihana olakino a kaulana hoʻi, ʻo ka lāʻau anti-kūnewa ʻo ia ka ʻike mua, ka pale ʻana, a me ka mālama ʻana i nā maʻi e pili ana i ka makahiki. He ʻokoʻa ʻokoʻa kēia mai ke kuʻi ʻana i ke kaʻina hana ʻelemakule ponoʻī, a ke loaʻa nei i kēia manawa nā ʻano laulā a me nā hoʻolālā. ʻO kahi laʻana ʻo Alzheimer lapaʻau, maʻi e pili ana i ka ʻelemakule.
-Ma ke kaiāulu ʻoihana ʻoi aku ka nui - i komo pū me nā ʻoihana hoʻopunipuni a nui ʻole paha - he anti waiwai ka anti-kūnewa a he ala i hōʻike ʻia e hoʻonui ai i nā kūʻai aku.

Ke noi ʻana i ka pauka antiaging

I kēia hiʻohiʻona, lilo nā huahana anti-kahiko i mea kaulana a kaulana loa. Pākuʻi ʻia ka palapala noi:
-O nā huahana mālama
-O nā huahana olakino olakino
-Na kumu inu okoa
-ʻO ka huahana-huahana

ʻO ka mālama ʻana i ka ʻelemakule & Alzheimer

Hoʻomaopopo pinepine ʻia ka Dementia me ka makahiki. E pili ana i 3% o ka poʻe ma waena o nā makahiki 65 a me 74, 19% ma waena o 75 a me 84, a kokoke i ka hapalua o ka poʻe i ʻoi aku i ka 85 mau makahiki i loaʻa i ka dementia. nā maʻi o ka maʻi ʻo Alzheimer, maʻi cerebrovascular, maʻi ʻo Parkinson a me ka maʻi ʻo Lou Gehrig.
ʻO ka ʻelemakule ka mea nui o ka pilikia no ka maʻi o Alzheimer. ʻO Alzheimer kahi ʻano dementia e kumu ai nā pilikia me ka hoʻomanaʻo, ka noʻonoʻo a me ka lawena. Hoʻolālā mālie nā ʻōuli o Alzheimer a ʻoi aku ka maikaʻi o ka hala ʻana o ka manawa, lilo i mea lawa e hoʻopilikia i nā hana o kēlā me kēia lā. "ʻIke mākou ʻo ka makahiki ka mea nui i hāʻawi i ka Alzheimer, no laila ʻaʻole ia he mea e kahaha ai i ka loaʻa ʻana o kahi pahuhopu lāʻau i hoʻopili ʻia i ka ʻelemakule,"
Ua hōʻoia ka FDA e like me Namzaric, kahi hui o Namenda (memantine) a me Aricept, no ka mālamaʻana i ke maʻi maʻi maʻi Alzheimer e like me ka maʻi.
Ua manaʻoʻiʻo Namendais (memantine) e hana ma o ka hoʻoponopono ʻana i ka glutamate, he mea koʻikoʻi pili lolo. I ka wā e hua ʻia ai ka nui o ka huakaʻi, hiki i ka glutamate ke alakaʻi i ka make ʻole o ka lolo. No ka mea ʻoi aku nā ʻano antagonist NMDA ʻokoʻa i ka inhibitors cholinesterase, hiki ke kuhikuhi ʻia i nā ʻano lāʻau like ʻole.
Nui nā huahana i ʻike ʻia he pono i ka mālama ʻana i ka maʻi o Alzheimer. E like me ka pauka J-147, pauka CMS121.

Nā huahana antiaging pauka

J-147 pauma (1146963-51-0): ʻO J147 kahi mea o ka elixir o ke ola o kēia manawa, ua hōʻike ʻia e mālama i ka maʻi o Alzheimer a hoʻohuli i ka ʻelemakule a kokoke i mākaukau no nā hoʻokolohua hoʻokolohua i loko o nā kānaka. ka mitochondrial ATP synthase — ka mea hiki ke lilo i mau pahuhopu lāʻau hou. Ua hoʻopau ʻo J147 i ka hoʻāʻo ʻana o ka lāʻau ʻino i koi ʻia e ka FDA i nā holoholona.
ʻO ka pauma acid Alpha-lipoic (1077-28-7): ʻO ka Alpha-lipoic acid kahi huaola e like me ka wikamina i kapa ʻia he antioxidant, ʻo ia hoʻi hiki ke hāʻawi i ka pale i ka lolo ma lalo o nā kumu o ka hōʻino a hōʻeha paha.
ʻIke ʻia ka hoʻohuihui alfa-lipoic e pale i kekahi ʻano o ka hōʻino o ka pehu i ke kino, a hoʻihoʻi hou i nā pae o ka bitamina e like me ka vitamin E a me ka vitamin C. Eia nō hoʻi kekahi hōʻike hōʻike ʻoi ka alpha-lipoic acid hiki ke hoʻomaikaʻi i ka hana a me ka hoʻopiʻi ʻana i nā neurons i ka maʻi diabetes.
ʻO ka lilo ʻana o ka hoʻomanaʻo he mea hopohopo maʻamau ma waena o nā pākeke kahiko.Manini ʻo ia ka pōʻino mai ka hoʻoweliweli ʻana i ka pōʻai paʻakai i ka mea nui o ka hoʻomanaʻo ʻana.
Ma muli o ka alpha-lipoic acid kahi antioxidant ikaika, ua nānā nā noiʻi i kona hiki ke hoʻolohi i ka holomua o nā maʻi i hōʻike ʻia e ka nalo ʻana o ka hoʻomanaʻo, e like me ka maʻi Alzheimer.
ʻO ka huapalapala, ka ate, ka ʻōpū, ka spinach, broccoli, a me nā mea kanu nā puna maikaʻi o ka waika alpha-lipoic.
CMS121 pauka (1353224-53-9): ʻO nā Geroprotector nā mea i hiki ke hoʻōlohi i ka nui o nā makahiki o ka holoholona e ke kau ʻana i nā kaʻina ʻelemakule. Nānā ka noiʻi hou i nā hui a ʻike ʻia kekahi mau mea e pale aku i nā neurons mai ka hōʻino ʻana ma ka hoʻolohi ʻana i kahi kaʻina ʻelemakule; ua kapa ʻia nā mea noiʻi he geroneuroprotektor.
Ma ka hoʻohana ʻana i kēia mau pūhui e like me ke kumu, ua hoʻokumu nā mea noiʻi i ʻekolu mau moho alzheimer i kapa ʻia CMS121, CAD31, a me J147; Ua hoʻohana pololei lākou i ka iʻa a me ka curcumin pololei. Hōʻike ka hui i kēia mau mea ʻelima o kēia mau pūhui e hōʻemi ana i nā biomarkers o ka wā kahiko, hoʻonui i ke ola median o nā kiʻi a me nā lele, a hoʻemi i nā hōʻailona o ka dementia.

Ke hanana o ka ʻelemakule

ʻO ka ʻōpū ka hopena o ka manawa ma ke kino o ke kanaka, a e kau ʻia ma nā pae he nui.
-ʻOki i hoʻopaʻa ʻia. Nā kelepona i haku ʻia ma muli o ka nui o nā manawa i hoʻopili ai. Hiki i kahi pūnaewele ke hoʻopihapiha e pili ana i ka manawa he 50 ma mua o ka mana o ka genetic hiki ʻole ke kope kope pono ʻia, kahi kūpono no nā telomeres pōkole. ʻO ka ʻoi aʻe o ka hōʻino ʻia e hana ʻia e nā maʻi a me nā mea ʻē aʻe, ʻoi aku ka nui o nā sela e hoʻomaʻamaʻa.
-ʻO ka hānau pakeke. Hoʻokomo ka nui o nā ʻōiwi i ka pākeke, ʻoiai ka wā ulu a me nā wā ʻōpio. Holoi nā pae kiʻekiʻe ma ke ola. Lawe ʻo Puberty i nā huehue a me nā pores nui. Ke ulu nei mākou i ka ulu ʻana o ka loli o ka hormonal i ke kino maloʻo a me ka menopause.
–Na wahi i hōʻino ʻia. ʻOkoʻa ka pau ʻole. Hōʻailona i nā meaʻala, ka lā, nā meaʻai maikaʻi, ka haumia, a me ka uahi e loaʻa i ka nui o ke kino. I ka hala ʻana o ka manawa, hiki i kēia mau kumu waho ke alakaʻi i ka pōʻino o ke kino a hāʻule ke kino ma hope o kona hiki i ka mālama a hoʻomaikaʻi i nā pūʻulu, nā palahala, a me nā kino.
-ʻO ka wā kahiko. Ke hele nei ʻoe i kou lā, e hoʻohuli mau ana kāu mau cell i ka meaʻai i mea e ikaika ai, ka mea e hoʻoulu ʻia e nā huahana e hiki ke hoʻopōʻino. ʻO ke kaʻina o ka metabolizing a hana i ka hopena o ka ikehu i ka hōʻeha i ke kino i ka manawa. Manaʻo kekahi poʻe e hoʻolohi i ka kaʻina loina metabola ma o nā hana e like me ka laʻana o calorie e lohi i ka lohi ʻana i nā kānaka.
Nā hōʻailona maʻamau o Alzheimer e pili ana i ka hiamoe ʻana, ke ʻauʻau hele ʻana, ka haunaele, ka hopohopo, ke kīwaha, hoʻomaha ʻole, a me ke kaumaha. Ke aʻo nei nā kānaka ʻepekema i ke kumu e kū ʻia ai kēia mau maʻi a ke noiʻi nei i nā lāʻau hou - ʻo ka lāʻau lapaʻau a me ka nondrug - e hoʻokele iā lākou.

Reference:

1. ʻO Mortimer RK, Johnston JR (1959). "Ke ola ola o nā huina hū pākahi". Kūlohelohe. 183 (4677): 1751–1752. Bibcode: 1959Natur.183.1751M. hana: 10.1038 / 1831751a0. hdl: 2027 / mdp.39015078535278. PMID 13666896
2. Hōʻike ka lāʻau lapaʻau hoʻāʻo i ka maʻi ʻo Alzheimer e hōʻike i nā hopena anti-ʻelemakule "(Press release). Ke Kula ʻo Salk. 12 Nowemapa 2015. kiʻi ʻia ʻo Nowemapa 13, 2015.
3. Hoʻomaopopo nā kānaka noiʻi i ka māka mole o J147, kahi e hoʻokokoke nei i nā hoʻokolohua hoʻokolohua e mālama ai i ka maʻi ʻo Alzheimer ”. Ua kiʻi ʻia 2018-01-30.
4. Ka Hoʻohuli o nā Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature Peter T. Nelson, Irina Alafuzoff, Eileen H. Bigio, Constantin Bouras, Heiko Braak, Nigel J. Cairns, Rudolph J. Castellani, Barbara J. Crain, Peter Davies, Kelly Del Tredici, Charles Duyckaerts, Matthew P. Frosch, Vahram Haroutunian, Patrick R. Hof, Christine M. Hulette, Bradley T. Hyman, Takeshi Iwatsubo, Kurt A. Jellinger, Gregory A. Jicha, Enikö Kövari, Walter A Kukull, James B. Leverenz, Seth Love, Ian R. Mackenzie, David M. Mann, Eliezer Masliah, Ann C. McKee, Thomas J. Montine, John C. Morris, Julie A. Schneider, Joshua A. Sonnen, Dietmar R. Thal, John Q. Trojanowski, Juan C. Troncoso, Thomas Wisniewski, Randall L. Woltjer, Thomas G. Beach J Neuropathol Exp Neurol. Palapala kākau; loaʻa ma PMC 2013 Jan 30. Paʻi ʻia ma ka palapala hoʻoponopono hope loa e like me: J Neuropathol Exp Neurol. 2012 Mei; 71 (5): 362–381. hana: 10.1097 / NEN.0b013e31825018f7

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