Oleoylethanolamide (OEA): kahi wai momona hōʻemi e kōkua ana e hoʻokele i ka hana

He aha ka Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) he mea hoʻokonukonu kūlohelohe o ke kaupaona, cholesterol, a me ka makemake Hoʻohui ʻia ka metabolite i nā mea liʻiliʻi i loko o nā ʻōpū liʻiliʻi. ʻO ke kinikini kūmole ke kuleana no ka manaʻo o ka piha ma hope o kou lawe ʻana i ka meaʻai. Kōkua ʻo Oleoylethanolamide i ka hoʻoponopono ʻana i ka momona o ke kino e ka hoʻopili ʻana iā Peroxisome proliferator-activated alpha receptor alpha (PPAR-Alpha). Hoʻonui kēia metabolite kūlohelohe i ke kino momona momona a hoʻomaopopo i kou lolo ua lawa ʻoe i ka meaʻai a pono ʻoe e haʻalele i ka ʻai ʻana. Hoʻonui pū ʻo Oleoylethanolamide i nā lilo calorie pili ʻole i ka hana.

Pehea e hana ai ʻo Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) Ke hana o ka hana

OleoyialeOEA) e hana ana me he mea hoʻokaumaha ʻaina. ^ E Ha yM. ʻO ka Oleoylethanolamide ke kau nei i kāu kaʻai ʻana o ka meaʻai ma ka hoʻouna ʻana i nā hōʻailona i ka lolo i ka haʻi ʻana i ka piha ʻana iā ʻoe, a ʻo ka manawa kēia e hoʻohiolo i ka ʻai ʻana. Ma kahi hopena, lawe ʻoe i ka liʻiliʻi o nā meaʻai i kēlā me kēia lā, a hoʻopau ke kino i ka hoʻouka hou ʻana i ke kaupaona hou ma ka manawa lōʻihi.

Oleoylethanolamide (OEA) (111-58-0) hana ʻia a hoʻoneʻe ʻia i ka pā liʻiliʻi liʻiliʻi mai ka waika oleic i loaʻa mai i ka meaʻai. ʻO ka meaʻai me nā momona momona e hiki ke kāohi i ka hana o Oleoylethanolamide ma ka palupalu liʻiliʻi proximal.

ʻO ka Oleoylethanolamide hoʻohaʻahaʻa i ka ʻai ʻana i ka meaʻai ma o ka hoʻoulu ʻana i ka circuitache brain circuitry, o hometaticatictocin, a me nā ala hedonic dopamine. Ke ʻike nei ia hiki hiki iā Oleoylethanolamide ke komo i ka hōʻailona inoa CB1R, inā he mea hoʻoikaika ʻia e alakaʻi i ka nui o ka ʻai o ka meaʻai. ʻO ka Oleoylethanolamide e hōʻemi i ka lawe ʻana i nā lipid i loko o ka adipocytes i ka haʻahaʻa o ka momona momona.

A OEA kekahi e hana pono ai i kahi mea i kapa ʻia ʻo PPAR a hoʻohaʻahaʻa i ka mālama ʻana i nā momona a hoʻonui i ka wela o ka momona. I kēlā me kēia manawa e ʻai ai i ka ʻai, e kū ana ke kiʻekiʻe o ka OEA a hāʻule kou makemake. Hana kēia no ka mea ua pili nā nano sensory i kou lolo e hoʻomaopopo iā ʻoe e piha ʻoe i ka PPAR-α. ʻO PPAR-α ka loulouleʻa o ka neʻe loulou o ka lula e hoʻopili ʻia ana i nā ala homeostasis i ke ala a me ka hōʻike o ka lipid metabolism.

Hōʻike ʻo Oleoylethanolamide (OEA) i nā hiʻohiʻona āpau e wehewehe i nā kuhi satiety e komo ai:

• Ke hōʻike nei i ka hānai me ka hoʻonui ʻana i ka manawa manawa ma waena o ka pāʻina a i ka pāʻina ʻē aʻe;
• Kāohi ʻia kona hana ʻia e nā mea i loaʻa o nā mea kanu ʻana
• Hōʻalo ʻia kona mau pae i ka loli o ka circadian.

Loaʻa ʻia ʻo Oleoylethanolamide (OEA) i nā pōmaikaʻi

Loaʻa ia ʻo Oleoylethanolamide a me nā hopena kaumaha momona keu;

i. ʻO ka hoʻemi ʻana i ka leʻaleʻa hoʻowalewale i ka hormone kaulana e ʻike ʻia ʻo Ghrelin

Ua hoʻolako ʻia nā kuhi Peripheral o OEA i ka lāʻau rodents e hoʻokē ana lākou no ka lā hoʻokahi i hoʻohaumia i ka hormone ghrelin i loko o kahi mau minuke 120, akā ma hope o 6 mau hola, he nui ka haʻahaʻa o kēia hormone ma ka 40 a 50 paha. Eia nō naʻe, ʻaʻohe hopena o Oleoylethanolamide i ka paʻakikī o kēia makemake i ka hoʻōla ʻana i ka hormone i loko o nā rodents hānai. Hoʻomaopopo kēia i ka hana nui o ka OEA ma ka hoʻemi ʻana i nā pae ghrelin inā lawe ʻia ma mua o ka papaʻaina.

ii. Ke hoʻonui nei i ka pae o ka pohō o ka momona o ke kino

Hoʻohana ka ʻβeta-adrenergic receptors e hoʻoulu i ka lilo nui o ke kino a me ka hoʻoulu ʻana i ka mea hōʻala o βeta3-adrenergic i loaʻa i ka hoʻemi ʻana i ka ʻaina meaʻai a me ka hoʻonui nui ʻana o ka momona momona i nā kahe. Hana ʻia ka mea ʻona e ka hoʻōla ʻana i nā protein me ka UCP1.

A ʻo kahi hopena, ʻo ka mālama pū ʻana o ag3 agonist a me ka ʻoleoylethanolamide peripheral injection me he mea lā he maikaʻi i ka hoʻoliʻiliʻi ʻana i ka ʻai a me ka maikaʻi o ka hoʻohaʻahaʻa ʻana i ka momona e pili pū ana me ka piʻi ʻana o ka lilo o ka ikehu. ʻO ka piʻi ʻana o nā pae o UCP1 a me PPARα (i manaʻo ʻia e hōʻike i ka hoʻonui ʻana o ka lilo o ka ikehu) i loko o nā meaola ʻeleʻele a me nā keʻokeʻo keʻokeʻo e pili ana i ka hoʻonui ʻana i nā biomarkers mitochondrial.

No laila, ʻōpiopio ka OEA e hoʻomaikaʻi i ka hopena metabolism mitochondrial a me nā hana thermogen i loko o nā rodents ma nā kōlio adipose brown a keʻokeʻo, ma ka pauku oleoylethanolamide like like me ka mea i mālama ai i ka momona.

iii. Ke hoʻohaʻahaʻa nei i ka pae o ka Peptide YY (Hōʻea-Hoʻoikaika a Stimulate)

ʻO nā kuʻina o 5mg / kg Oleoylethanolamide i nā koʻokoʻo i hoʻemi ʻia i ka manawa ka nui o ka peptide hormone YY i hana ʻia i loko o ka ʻōpū o ka moku hānai a me ka meaʻai ʻole.

ʻO Oleoylethanolamide (OEA) Kōkua i ka ʻĀina hana?

Ae. Oleoylethanolamide hōʻemi kōkua hoʻoluhi kōkua e kōkua i ʻohiʻohi ʻaʻai ma ka hoʻokū ʻana i ka PPAR ma laila e hōʻemi ai i ka mālama ʻana i nā momona a me ka hoʻonui ʻana i ka momona o nā momona. Ke lawe ʻoe i kāu ʻai, e piʻi ka nui o Oleoylethanolamide a hoʻohaʻahaʻa kou makemake i ka wā e hoʻouna ʻia ai nā hōʻailona i kou lolo e hoʻolaha ana i ka lolo a ʻoluʻolu ʻoe.

Nui nā noiʻi ʻepekema i hōʻoia i kēia hopena. I ka makahiki 2004, no ka ʻike ʻana, ua noiʻi nā mea noiʻi Nīmela i nā isika i hoʻoiho ʻia i ka meaʻai no hoʻokahi lā. Hāʻawi lākou iā lākou i OEA a ʻike i ka nui o nā meaʻai a lākou i hōʻemi ai ma ka 15.5%. Ma nā ʻōlelo maʻalahi, ua huli ʻo Oleoylethanolamide (OEA) i ka hoʻololi no ka pōloli i ka CNS (Central Nervous System).

ʻO Oleoylethanolamide (OEA) Hana

ʻO ka dosle oleoylethanolamide i ʻōlelo ʻia ʻia ʻo ia i kapohima 200mg i ka wā i lawe ʻole ʻia ai. Ke hui pū ʻia me nā mea momona kaumaha ʻē aʻe, e hoʻohaʻahaʻa ʻia ka ʻōwili OEA ma waena o 100mg a me 150mg.

Manaʻo ʻia e lawe ʻoe i ka oleoylethanolamide hoʻohui 30 mau minuke ma mua o ka pāʻina a me ke kakahiaka ʻaina; E ʻoluʻolu ʻoe i ka ʻoluʻolu i ka wā ʻai a hoʻopau ʻoe i ka ʻai ʻana.

Ua noi ʻia e noiʻi hiki iā ʻoe ke hoʻohaʻahaʻa a hoʻonui i nā maʻi i kēlā me kēia lā e like me kou palaka. I ka laʻana, inā kaupaona ka 150lb, lawe ʻoe a 100mg. Hiki i kahi kanaka 200lb ke lawe aku i 150mg a kahi kanaka 250lb e lawe i 180mg o ka hoʻohui.

Oleoylethanolamide (OEA) Loaʻa ʻaoʻao

ʻO nā hopena ʻaoʻao o Oleoylethanolamide hiki ke lilo i ka hopohopo koʻikoʻi ma waena o nā mea hana mea makemake e makemake e hoʻopili i kēia mea mana ikaika i ko lākou kumu hoʻolimalima momona momona.

Ma hope o kahi loiloi hohonu hohonu o ka ʻikepili ʻike āpau i loaʻa, ʻo US FDA (Food and Drug Administration) ʻaʻohe kumu e pili ana i ka palekana o kēia molekele maoli. ʻO RiduZone ka pauma OEA mua i hōʻailona ʻia ma 2015.

ʻOEA kahi hana o ka metabolic ole ole acid a ʻo kahi ʻāpana o kahi papaʻai i kēlā me kēia lā. I piha piha e lawe pū ʻia ʻo Oleoylethanolamide supplemental no ka mea ʻaʻohe hopena koʻikoʻi e hōʻike ʻia nei.

Oleoylethanolamide (OEA) Ke kūʻai

Hiki iā ʻoe ke kiʻi i kahi oleoylethanolamide kūʻai mai i nā pūnaewele lāʻau kūlohelohe a me ke kino. Akā, pono ʻoe e makaʻala no ka mea ʻaʻole loa nā mea lako. E ʻike pono e heluhelu i kā lākou loiloi oleoylethanolamide e ʻike i ka ʻike i ka ʻike o kā lākou mea kūʻai aku ma mua.

Ke noʻonoʻo nei ʻoe i kahi e loaʻa ai ke oleoylethanolamide no ke kūʻai? Mai hopohopo; hiki iā ʻoe ke kūʻai aku i ka oleoylethanolamide online ma kā mākou pūnaewele pūnaewele. He poʻe kaulana mākou a me ka ʻike OEA mea hoʻolako a hiki iā mākou ke hāʻawi iā Oleoylethanolamide (OEA) ma USA a me kekahi mau ʻāina ʻē aʻe a puni ka honua. He maʻalahi kā mākou kaʻina hoʻonohonoho akā palekana a palekana hoʻi. Hāʻawi mākou i kā mākou huahana i nā peʻa paʻa paʻa a nani hoʻi e hōʻoia i ka palekana a pale i nā maʻi.

Paukū ma:

Kauka Liang

Co-hoʻokumu, alakaʻi alakaʻi o ka ʻoihana o ka ʻoihana; Loaʻa ʻo PhD mai ke Kulanui ʻo Fudan i ka kemika kemika. Ma mua o ʻeiwa mau makahiki o ka ʻike i ke kahua synthetic organic o ka chemistry lāʻau. ʻIke waiwai i ka kemika kombinatorial, kemika lāʻau a me ka synthesist custom a me ka hoʻokele papahana.

E hoʻomaopopo ':

• Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Pepe o rimonabant, he mea blocker cannabinoid-1, ma ke kaupaona ʻana a me nā mea e pili ana i ka pilikia ma ka momona o ka momona a i ka momona: ʻO RIO-ʻAmelika Huipū. Ka Nīnau o ka ʻAmelika Kauka ʻAmelika. 2006; 295 (7): 761–775.
• Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Hoʻonui ka hoʻonui o ka hoʻoliʻiliʻi oleoylethanolamine i ka ʻōpū liʻiliʻi o ka python Burmese (Python molurus)". ʻO Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412.
• ʻO Sarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. ʻOi ka molekina a me ka makemakeʻai: ka hihia o oleoylethanolamide. Nā Kūlana Nervous Pūnaehana kikowaena i ka lāʻau lapaʻau lāʻau. 2013; 13 (1): 88–91.
• Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (2006). "Deorphanization o kahi G receptor i hoʻohui pū ʻia me ka protein no ka oleoylethanolamide a me kāna hoʻohana i ka loaʻa ʻana o nā mea hana hypophagic liʻiliʻi liʻiliʻi. Pūnaewele Metab. 3 (3): 167–175.

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