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ʻO Urolithin He Powder

ʻO Urolithin A, kahi metabolite ʻōpū o microbial o ellagic acid, hana i ka anti-inflammatory, antiproliferative, a me nā waiwai antioxidant. Hoʻokomo ʻo Urolithin A i ka autophagy a me ka apoptosis, kaohi i ka holomua o ke kolo, a keakea i ka synthes DNA. ʻAʻole ʻike ʻia ʻo Urolithin A i nā kumuwaiwai. Pili ka nui o kona bioavailability i kēlā me kēia microbiota haku mele, no ka mea he mau koʻohune wale nō i hiki ke hoʻolilo i nā ellagitannins i mau urolithins.

Hana: Hana Hana
pūʻolo: 1KG / ʻeke, 25KG / pahu
Hiki i ka Wisepowder ke hana a hāʻawi i ka nui. ʻO nā hana a pau ma lalo o ke kūlana cGMP a me ka ʻōnaehana hoʻomalu maikaʻi koʻikoʻi, loaʻa nā palapala hoʻāʻo a pau.
Māhele:

Urolithin A pauda ʻIkepili Base

inoa ʻO Urolithin He Powder
CAS 1143-70-0
Purity 98%
Inoa inoa inoa 3,8-Dihydroxybenzo [c] chromen-6-hoʻokahi
'O Synonyms 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-one; 3,8-DIHYDROXYDIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-one; Puka Castoreum I; ʻO Urolithin A; 6H-Dibenzo (B, D) pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-one
Ka Lā Molecular C13H8O4
Molecular Weight 228.2
Point Hoʻolālā > 300 ° C
InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N
ano paa
Keʻano Pauka melemele māmā
Half Ole
Palekana Hoʻopiliʻia i DMSO (3 mg / mL).
pūnaewele Kūlana: Maloʻo, ʻeleʻele a ma 0 - 4 C no ka wā pōkole (mau lā a i mau pule) a i ʻole -20 C no ka wā lōʻihi (mau mahina i mau makahiki).
noi ʻO Urolithin A kahi metabolite o ellagitannin; Hoʻolapa i nā lāʻau lapaʻau
Hōʻike hōʻike palapala Available

 

ʻO Urolithin He Powder Hōʻike Kūkākūkā

ʻO Urolithin He paukū kahi hui metabolite e pili ana i ka hoʻololi ʻana o ellagitannins e nā ʻōpala pūpū a he mea hoʻokomo i ka mitophagy. Hoʻololi ʻo Urolithin i ka mitochondria mai CI- i ka hanu C-driven, hoʻonui i ke ola a hoʻomaikaʻi i ka hana muscle. Pili ia i ka papa o nā mea hoʻohui i ʻike ʻia ʻo benzo-coumarins a i ʻole dibenzo-α-pyrones. ʻO nā mea i hele mua - nā ʻeleka ellagic a me nā ellagitannins - aia a puni i ke ʻano, e like me nā mea kanu ʻai, e like me nā pomegranates, strawberry, raspberries, a me nā walnuts. Mai ka makahiki 2000, ua mālama ʻia ka urolithin A i nā loiloi mua e pili ana i nā hopena biological hiki ke loaʻa.

Hiki i ka Urolithin A pauka ke hoʻomaikaʻi i ka maikaʻi a me ka hana o mitochondria, a hoʻonui i ka ikaika a me ke ahonui o nā mākua ʻelemakule. ʻO ia wale nō ka huahana maoli i hōʻoia ʻia e hoʻomaka hou i ka autophagy mitochondrial a hoʻohuli i ka ʻelemakule o nā mākala.

ʻO nā Urolithins he microflora kanaka metabolite o nā dietivic acid acid elagic, e like me ellagitannins. Hana ʻia lākou i loko o ka

ʻōpū o ke kanaka, a loaʻa i ka mimi i ke ʻano o ka urolithin B glucuronide ma hope o ka lawe ʻia ʻana o ellagitannins-i loaʻa nā meaʻai e like me

pomeraite, strawberry, raspberry ʻulaʻula, walnuts a i ʻole ʻulaʻula ʻulaʻula kahiko.

I loko o ka ʻōpū o ka ʻōpū e nā bacteria, e hoʻohuli ʻia nā ellagitannins a me nā punicalagins i nā urolithins, ka mea i ʻike ʻole ʻia

hana olaola i loko o nā kānaka. Urolithins metabolites o ka pomegranate wai ellagitannins localize kikoʻī i loko o

ka gland prostate, kolona, ​​a me nā ʻōpū o nā iole.

Hōʻike ʻo Ellagitannins i ka bioavailability haʻahaʻa a hoʻololi ʻia i loko o ka ʻōpū i el acid acid a me kāna microbiota metabolites.

Loaʻa nā urolithins i ka plasma ma ke ʻano he glucuronides ma nā haʻahaʻa haʻahaʻa.

Pili ka hana o Urolithins i ka enterotype microbiome ʻōpū. Hōʻike nā kānaka e hana ana i nā urolithins i kahi ʻoi aku ke kiʻekiʻe

o ka Clostridium leptum hui o Firmicutes phylum ma mua o Bacteroides a i ʻole Prevotella

 

Urolithin He moʻolelo pauka

I loko o nā keʻena hoʻokolohua, ua hōʻike ʻia ka urolithin A pauma e hoʻokomo i ka mitophagy, kahi hana hou ʻana o ka mitochondria e autophagy, kahi hana e hoʻomaʻemaʻe i ka mitochondria hemahema ma hope o ka hōʻino a me ke koʻikoʻi, a lilo i mea liʻiliʻi i ka wā ʻelemakule. Ua ʻike ʻia kēia hopena i nā ʻano holoholona like ʻole (nā hunaola mammalian, rodents a me C. elegans).

 

Urolithin He mea hoʻohana pauka

ʻO Urolithin A pauka i mea e hoʻohana ai ma ke ʻano he mea hana i nā meaʻai i wae ʻia a i ʻole no ka hoʻohana dietary kūikawā i nā huahana pani pāʻina e pili ana i kāna hana nutritive i ke kākoʻo ʻana i ke olakino mitochondrial.

 

Urolithin A pauka ʻOi aku ka noiʻi

ʻAʻole ʻike ʻia ʻo Urolithin A i kekahi meaʻai. Hana ia ma ke ʻano he hopena o ka loli o nā ellagic acid a me nā ellagitannins e ka microflora ʻōpū i nā kānaka. Nā hualoaʻa Ellagic ponoʻī mai ka hydrolysis o ellagitannins i loko o ke kō i ke alo o ka wai.

ʻO nā kumuwaiwai o ellagitannins: pomegranates, nut, kekahi hua (raspberries, strawberry, blackberry, cloudberry), kī, muscadine grapes, he nui nā hua tropical, a me nā waina ʻelemakule (papa ma lalo).

ʻO ka hoʻololi ʻana o nā waika ellagic i urolithin A kaukaʻi ʻia i kēlā me kēia microflora haku mele a hiki ke loli nui.

 

ʻO Urolithin He Hōʻike Paʻa

  1. ʻO Paller CJ, Pantuck A, Carducci MA. ʻO kahi loiloi o ka pomeraite i ka maʻi ʻaʻai prostate. ʻO Prostate Cancer Prostatic Dis. 2017 Apr 25. doi: 10.1038 / pcan.2017.19. [Epub ma mua o ka paʻi] Nānā. ʻO PubMed PMID: 28440320.
  2. Ito H. Metabolites o ka ellagitannin geraniin a me kā lākou mau hana antioxidant. ʻO Planta Med. 2011 Jul; 77 (11): 1110-5. hana: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Loiloi. ʻO PubMed PMID: 21294073.
  3. Ishimoto H, et al. I loko o vivo anti-inflammatory a me nā waiwai antioxidant o ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011ʻOkakopa 1; 21 (19): 5901-4.

 

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